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Contrave® (naltrexone HCI/bupropion HCl) is a prescription weight-loss medicine that may help adults with obesity (BMI greater than or equal to 30 kg/m2), or who are overweight (BMI greater than or equal to 27 kg/m2) with at least one weight-related medical condition, lose weight and keep the weight off. Contrave® should be used along with diet and exercise.
Important Safety Information, including Boxed Warning
One of the ingredients in Contrave®, bupropion, may increase the risk of suicidal thinking in children, adolescents, and young adults. Contrave® patients should be monitored for suicidal thoughts and behaviors. In patients taking bupropion for smoking cessation, serious neuropsychiatric adverse events have been reported. Contrave® is not approved for use in children under the age of 18.
Stop taking Contrave® and call a healthcare provider right away if you experience:
Do not take Contrave® if you:
Before taking Contrave®, tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other medicines while you are taking Contrave® unless your healthcare provider says it is okay.
Tell your healthcare provider about all of your medical conditions including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant; or breastfeeding.
Contrave® may cause serious side effects, including:
The most common side effects of Contrave® include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea.
These are not all the possible side effects of Contrave®. Tell your healthcare provider about any side effect that bothers you or does not go away.
Use of Contrave®
Contrave® is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.
Contrave® is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation).
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.